ParkinsonCanadaV1, Main, Exploration, bibRecord, 002B01

Survival in Parkinson disease: Thirteen-year follow-up of the DATATOP cohort

Identifieur interne : 002B01 ( Main/Exploration ); précédent : 002B00; suivant : 002B02

Survival in Parkinson disease: Thirteen-year follow-up of the DATATOP cohort

Auteurs : C. Marras [Canada] ; M. P. Mcdermott [États-Unis] ; P. A. Rochon [Canada] ; C. M. Tanner [États-Unis] ; G. Naglie [Canada] ; A. Rudolph [États-Unis] ; A. E. Lang [Canada]

Source :

Neurology [ 0028-3878 ] ; 2005.

RBID : Pascal:05-0101012

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Survie, Parkinson maladie.

English descriptors

KwdEn :
- Nervous system diseases, Parkinson disease, Survival.

Abstract

Objective: To investigate predictors of survival in Parkinson disease (PD). Methods: Vital status was determined in 800 subjects enrolled in a clinical trial of deprenyl (selegiline) and tocopherol 13 years earlier. Results: Two hundred ninety-six deaths were recorded. There was no difference in the standardized mortality ratios across gender or age group. In univariate analyses, PD-specific variables associated with mortality were increased symmetry of parkinsonism, gait dysfunction as an initial symptom, severity of parkinsonism, and rate of worsening of parkinsonism prior to study enrollment. Cumulative exposure to deprenyl was not associated with mortality. In multivariable analysis, severity of parkinsonism and rate of worsening of parkinsonism remained associated with mortality. A poorer response to levodopa was associated with increased mortality independent of disease severity or dosage of levodopa. Results were unchanged when the analysis was restricted to 747 subjects maintaining a most likely diagnosis of PD throughout 6 years of active follow-up. Conclusions: Parkinson disease did not affect survival differently across gender or age groups in this selected group of otherwise healthy clinical trial participants. Severity and rate of worsening of parkinsonism and response to levodopa are strongly related to survival.

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Objective: To investigate predictors of survival in Parkinson disease (PD). Methods: Vital status was determined in 800 subjects enrolled in a clinical trial of deprenyl (selegiline) and tocopherol 13 years earlier. Results: Two hundred ninety-six deaths were recorded. There was no difference in the standardized mortality ratios across gender or age group. In univariate analyses, PD-specific variables associated with mortality were increased symmetry of parkinsonism, gait dysfunction as an initial symptom, severity of parkinsonism, and rate of worsening of parkinsonism prior to study enrollment. Cumulative exposure to deprenyl was not associated with mortality. In multivariable analysis, severity of parkinsonism and rate of worsening of parkinsonism remained associated with mortality. A poorer response to levodopa was associated with increased mortality independent of disease severity or dosage of levodopa. Results were unchanged when the analysis was restricted to 747 subjects maintaining a most likely diagnosis of PD throughout 6 years of active follow-up. Conclusions: Parkinson disease did not affect survival differently across gender or age groups in this selected group of otherwise healthy clinical trial participants. Severity and rate of worsening of parkinsonism and response to levodopa are strongly related to survival.</div>
</front>
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<name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A. E." last="Lang">A. E. Lang</name>
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<name sortKey="Naglie, G" sort="Naglie, G" uniqKey="Naglie G" first="G." last="Naglie">G. Naglie</name>
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</country>
<country name="États-Unis"><noRegion><name sortKey="Mcdermott, M P" sort="Mcdermott, M P" uniqKey="Mcdermott M" first="M. P." last="Mcdermott">M. P. Mcdermott</name>
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<name sortKey="Rudolph, A" sort="Rudolph, A" uniqKey="Rudolph A" first="A." last="Rudolph">A. Rudolph</name>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Survival in Parkinson disease: Thirteen-year follow-up of the DATATOP cohort

Survival in Parkinson disease: Thirteen-year follow-up of the DATATOP cohort

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri